Sadaf Sadeghi Yazdankhah
Assistant professor, Iran
Title: Management of postoperative pain after Lumbar surgery; pregabalin for one day and 14 days; a randomized, triple-blinded, placebo-controlled study
Biography
Biography: Sadaf Sadeghi Yazdankhah
Abstract
Objectives: Despite the progress in understanding acute pain physiology during recent decade, eighty percent of patients still suffer from post-operative discomfort. Pregabalin is an anticonvulsant agent that is approved for painful neuropathies in diabetic patients and post herpetic neuralgia. The main objective of the present study was to compare the improvement in post-operative pain management and patient lifestyle in 3 groups, as first group received placebo, second who received Pregabalin for one day and the last group those who received it for 14 days.
Methods: This was a prospective single center, randomized, triple-blind, 3-arm, parallel group study. In this triple-blind study, patients were allocated to 1 of 3 groups. All the patients were operated based on standard surgery techniques, bilateral foramenotomy and interlaminar discectomy. The first group received placebo for 14 days, the second group received Pregabalin 300mg 8 hours preoperatively and 150mg 12 and 24 hours postoperatively and for the rest of 13 days received placebo and the third group received Pregabalin 300mg eight hours preoperatively and 15omg every 12 hours postoperatively for 14 days. Name, age, gender, height, weight, education, duration of pain, past medical history, drug history ,total morphine requirement at the time of discharge and MRI findings of all the patients were recorded, also the Numerical scale system (NRS) and Oswestry low back pain disability index (ODI) questionnaire were completed for them .